Milk Thistle Extract

                                   
English Name:Milk Thistle Extract

Latin Name:Silybum Marianum

Other Name:Silymarin; Mary Thistle; Wild Artichoke; Silybum; Marian Thistle; St. Mary's Thistle; Lady Thistle; Holy Thistle



 

Molecular Structure of Silymarin

 





Silybin

Molecular Formula: C25H22O10 

Molecular Weight: 482.44 g/mol 

Cas Number: 22888-70-6 (65666-07-1)

EINECS  Number: 245-302-5 













[About Milk Thistle]

  Milk thistle is native to the Mediterranean, but is now widespread throughout the world. This stout thistle usually grows in dry, sunny areas. The stem branches at the top, and reaches a height of 4 to 10 feet. The leaves are wide, with white blotches or veins. The flowers are red-purple. The small, hard-skinned fruit is brown, spotted, and shiny. Milk thistle is easy to grow, and it matures quickly, in less than a year.

 



[Functions of Milk Thistle Extract]

1. Liver disease

Milk thistle (Silybum marianum) has been used since Greco-Roman times as an herbal remedy for a variety of ailments, particularly liver problems. In the late 19th and early 20th centuries physicians in the United States used milk thistle seeds to relieve congestion of the liver, spleen, and kidneys. Today, several scientific studies suggest that active substances in milk thistle (particularly silymarin) protect the liver from damage caused by viruses, toxins, alcohol, and certain drugs such as acetaminophen (a common over the counter medication used for headaches and pain; acetaminophen, also called paracetamol, can cause liver damage if taken in large quantities or by people who drink alcohol regularly.)

Many professional herbalists recommend milk thistle extract for the prevention and/or treatment of various liver disorders including viral hepatitis, fatty liver associated with long term alcohol use, and liver damage from drugs and industrial toxins such as carbon tetrachloride.

 

2. Mushroom Poisoning

Milk thistle has also been used as a preventive and/or antidote to poisoning by deathcap mushroom (Amanita phalloides). Animal studies have found that milk thistle extract completely counteracts the toxic effects of the mushroom when given within 10 minutes of ingestion. If given within 24 hours of ingestion, the herb significantly reduces the risk of liver damage and death.

 

3. Viral hepatitis

Despite the fact that milk thistle is widely used in the treatment of hepatitis (particularly hepatitis C), results from four viral hepatitis studies were contradictory. Some found improvements in liver enzyme activity while others failed to detect these benefits. None of the studies compared milk thistle with interferon or other medications for viral hepatitis.

 

4. Cancer

Preliminary laboratory studies also suggest that active substances in milk thistle may have anti-cancer effects. One active substance known as silymarin has strong antioxidant properties and has been shown to inhibit the growth of human prostate, breast, and cervical cancer cells in test tubes. Further studies are needed to determine whether milk thistle is safe or effective for people with these forms of cancer.

 

5. High cholesterol

One animal study found that silymarin (an active compound in milk thistle) worked as effectively as the cholesterol-lowering drug probucol, with the additional benefit of substantially increasing HDL ("good") cholesterol. Further studies in people are needed.



 

[Contraindications]

Side effects from milk thistle happen only rarely, but may include stomach pain, nausea, vomiting, diarrhea, headache, rash or other skin reactions, joint pain, impotence, and anaphylaxis (a life-threatening allergic reaction that causes throat tightness, shortness of breath, and, possibly, loss of consciousness.) The last two reactions listed are extremely rare.

Milk thistle should not be used by pregnant or breastfeeding women.





[Our Products]

1. Silymarin:    80% UV  (DAB 10)



2. Silymarin:   15%, 40%, 70% UV



3. Silymarin:   80%, Silybin 40% HPLC



4. Silymarin:   75%, Silybin 35% HPLC



5. Silymarin:   70%, Silybin 30% HPLC



6. Silymarin Extracted by Ethanol:    70%, 80% UV

Silymarin extracted with Ethanol solve the problem of residual organic solvents, it make the Silymarin more safety to human body.



7. Silymarin Extracted by Ethyl Acetate:

(1) Silymarin 80% UV

(2) Silymarin 58% HPLC

Ethyl Acetate has the characteristic of lower toxicity compare with Acetone, and it can extract higher assay Silymarin than Ethanol.



8. Water Soulble Silymarin:   20%, 40%, 45% UV

It is a new type Silymarin product, which is a compound of Silymarin and Meglumine. It solves the problem that Silymarin does not dissolve in water, the problem may influence the utilization ratio. Water Soluble Silymarin has all the efficacy of Silymarin, besides, it widens the using field of Silymarin, including function food, drinks and health products and cosmetics.



9. Silybin:   80%, 85%, 90%, 95%, 97%, 98%, 99% HPLC

Silybin is the main effective ingredient of Milk Thistle Extract, including Silybin and Isosilybin. It can dissolve in Methanol, Ethanol and acetone, but not in water. It has the efficacy of liver protecting, improve the function of liver, promote biliation and diminish liver inflammation. Silybin has a good curative effect to acute/chronic hepatitis, hepatocirrhosis and liver damage of intoxication, and it is the main raw material of medicinal derivative of Silybin.



10. Water Soulble Silybin (Silybin Meglumine):   Silybin Meglumine75% HPLC, Silymarin Meglumine 96% UV