Continuous Manufacturing of Oral Solid Dosages

                                   
Advantages of Continuous Manufacturing


	

		

			
General: Strengths of continuous processing in the context of mixing solids
			
Relevance for pharmaceutical solids production
		
	
	

		

			
Same equipment during clinical trials and commercial production
			
Shorter development time, as the same feeding/mixing module is used. No scale up needed. To increase the "batch size", you extend the production time.
		
		

			
Easy to integrate into an existing continuous process.
			
Compression, extrusion and roller compacting become continuous processes.
		
		

			
Continuous mixing system takes up less space, thanks to the compact dimensions of the equipment.
			
Amount of space required by a feeding/mixing module for 4-6 components is 2*2*2 meters
		
		

			
Less risk of demixing, as the process volume is smaller and there is no need to empty large-volume batch mixers or intermediate tanks. Much less material is stored temporarly.
			
Continuous mixer with a volume of 1-10 litres. Production time required to turn the raw material into a tablet = 5 minutes - "process intensification".
		
		

			
The fully automated process cuts operating costs. The manufacturing process and the product quality are assured by means of sophisticated measurement and control technology.
			
The continuous feeding and weighing technology represents an integrated P(process) A(nalytical) T(echnology) solution that can ensure a formulation accuracy of 0.1 - 0.5% thanks to its high-resolution timing and weighing.
		
		

			
Improved product quality - the highly homogeneous shear rate and limited residence time distribution mean that the product is subject to very even levels of stress.
			
Very gentle processing of sensitive products thanks to low speeds and minimal drop heights as well as short mixing times of less than 30 seconds.
		
		

			
 
			
Less waste.